Antihypertensive and cardiac effect of Zn-Telmisartan in ovariectomized spontaneously hypertensive rats.

MARTINEZ VR; DIAZ, RG; PEREZ, NG; VELEZ RUEDA, JO; LOFEUDO, JM; SILVA, MG; GIRONACCI, MM; PORTIANSKY EL; WILLIAMS, PAM; DE GIUSTI, VC

Berlin

Congreso; XXIV World Congress International Society for Heart Research; 2022

During menopause there exists an imbalance between the pressor Angiotensin II (AngII) and the protective (Ang 1-7) arms of the renin-angiotensin-system (RAS), which leadsto oxidative stress, hypertension and cardiac dysfunction1. Restoring RAS balance wouldprevent cardiovascular diseases in menopausal women. We have previously modified thestructure of telmisartan (Telm), an Ang II receptor blocker, with Zinc (ZnTelm),demonstrating a higher drug effectiveness2. In this work, we examined if chronic treatmentwith ZnTelm, in comparison with Telm alone, was a better alternative to preventcardiovascular damage during menopause. Spontaneously hypertensive rats (SHR)(female, 16-week-old, 180-200g) were sham-operated or bilateral ovariectomized (OVXSHR). OVX-SHR rats were randomly divided in 3 groups: no-treated (control), treated withTelm or treated with ZnTelm (10 or 11 mg/kg/day drinking water for 8 weeks). Results(n=6 per group) were analyzed by ANOVA. * p