INVESTIGADORES
MENCHON Silvia Adriana
artículos
Título:
Neuronal (Bi)Polarity as a Self-Organized Process Enhanced by Growing Membrane
Autor/es:
MENCHÓN, SILVIA ADRIANA; GÄRTNER, ANNETTE; ROMÁN, PABLO ; DOTTI, CARLOS
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Año: 2011 vol. 6 p. 2419001 - 2419011
ISSN:
1932-6203
Resumen:
Early in vitro and recent in vivo studies demonstrated
that neuronal polarization occurs by the sequential formation of two
oppositely located neurites. This early bipolar phenotype is of crucial
relevance in brain organization, determining neuronal migration and
brain layering. It is currently considered that the place of formation
of the first neurite is dictated by extrinsic cues, through the
induction of localized changes in membrane and cytoskeleton dynamics
leading to deformation of the cells' curvature followed by the growth of
a cylindrical extension (neurite). It is unknown if the appearance of
the second neurite at the opposite pole, thus the formation of a bipolar
cell axis and capacity to undergo migration, is defined by the growth
at the first place, therefore intrinsic, or requires external
determinants. We addressed this question by using a mathematical model
based on the induction of dynamic changes in one pole of a round cell.
The model anticipates that a second area of growth can spontaneously
form at the opposite pole. Hence, through mathematical modeling we prove
that neuronal bipolar axis of growth can be due to an intrinsic
mechanism.