INVESTIGADORES
GODOY HERZ Micaela Amalia
artículos
Título:
Transcriptional elongation and alternative splicing
Autor/es:
DUJARDIN, GWENDAL, LAFAILLE CELINA; PETRILLO, EZEQUIEL; BUGGIANO, VALERIA; GÓMEZ ACUÑA, LUCIANA I; FISZBEIN, ANA; GODOY HERZ, MICAELA A; NIETO MORENO, NICOLÁS; MUÑOZ, MANUEL; ALLO, MARIANO; SCHOR, IGNACIO; KORNBLIHTT, ALBERTO
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2012
ISSN:
1874-9399
Resumen:
Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
