Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial

MATAMOROS, GABRIELA; SÁNCHEZ, ANA; GABRIE, JOSÉ ANTONIO; JUÁREZ, MARISA; CEBALLOS, LAURA; ESCALADA, ANDRÉS; RODRÍGUEZ, CAROL; MARTÍ-SOLER, HELENA; RUEDA, MARÍA MERCEDES; CANALES, MARITZA; LANUSSE, CARLOS; CAJAL, PAMELA; ÁLVAREZ, LUIS; CIMINO, RUBÉN O; KROLEWIECKI, ALEJANDRO

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

NLM (Medline)

Año: 2021 vol. 73 p. 1203 - 1210

BACKGROUND: The efficacy of currently available anthelminthics against Trichuris trichiura infections is significatively lower than for other soil-transmitted helminths. The combination of ivermectin (IVM) and albendazole (ALB) has shown significant improvements in efficacy. METHODS: Safety and efficacy randomized controlled clinical trial comparing 3 experimental regimens against ALB monotherapy for the treatment of T. trichiura infections in northern Honduras. Infected children were randomized to 4 treatment arms: arm 1, single-dose ALB (400 mg); arm 2, single-dose ALB (400 mg) plus IVM (600 μg/kg); arm 3, ALB (400 mg) for 3 consecutive days; or arm 4, ALB (400 mg) plus IVM (600 μg/kg) for 3 consecutive days. Efficacy was measured based on the egg reduction and cure rates, both assessed 14-21 days after treatment, using the Kato-Katz method. Safety was evaluated by analyzing the frequency and severity of adverse events. RESULTS: Of 176 children randomized to 1 of the 4 treatment arms, 117 completed treatment and follow-up. The egg reduction rates for arms 1, 2, 3, and 4 were 47.7%, 96.7%, 72.1%, and 100%, respectively; with P values