Nanoparticle Concentration vs. Surface Area in the Interaction of Thiol Containing Molecules: Towards a Rational Nano-Architectural Design of Hybrid-Materials

GOEL, KESHAV; ZUÑIGA-BUSTOS, MATIAS; LAZURKO, CAITLIN; JACQUES, ERIK; GALAZ-ARAYA, CONSTANZA; VELENZUELA-HENRIQUEZ, FRANCISCO; PACIONI, NATALIA L.; COUTURE, JEAN-FRANÇOIS; POBLETE, HORACIO; ALARCON, EMILIO I.

ACS APPLIED MATERIALS & INTERFACES

AMER CHEMICAL SOC

Lugar: Washington; Año: 2019 vol. 11 p. 17697 - 17705

1944-8244

The effect of accounting for total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm which calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as 3D pseudo-spherical nanostructures. Our data indicate that not only the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces.