INVESTIGADORES
SPANEVELLO Rolando Angel
artículos
Título:
Synthesis of novel, highly potent cyclic-hexapeptide analogs of somatostatin. Potential application of orthogonal protection for affinity chromatography
Autor/es:
SPANEVELLO, R. A.; HIRSCHMANN, R.; RAYNOR, K.; REISINE, T.; NUTT, R. F.
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 1991 vol. 32 p. 4675 - 4678
ISSN:
0040-4039
Resumen:
The syntheses of new cyclic hexapeptides are described. These peptides potently displace [125I] CGP-23996 (des-Ala1, Gly2-desamino-Cys3[Tyr11]-dicarba3,14 SRIF) from SRIF receptors on AtT-20 cells. Two of these compounds are of potential value for the isolation of SRIF receptors by affinity chromatography. A key feature in the design was the use of orthogonal protection to provide selective covalent bonding to the solid support.
