Stereocontrolled Total Synthesis of (5S,6R)-, (5S,6S)-, (5R,6R)-, and (5R,6S)(7E,9E,11Z,14Z)-5,6-Dihydroxy-7,9,11,14-icosatetraenoic Acid (5,6-DiHETE) Methyl Esters

NICOLAOU, K. C.; RAMPHAL, J. Y.; PALAZON, J. M.; SPANEVELLO, R. A.

Angewandte Chemie

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 1989 vol. 28 p. 587 - 588

1433-7851

The (5S, 6R)-configurated title compound 1 is of interest as a biologically active metabolite of arachidonic acid. A method for the synthesis of 1 which also can be extended to the enantiomer and the two diastereomers now makes these compounds readily accessible in amounts satisfactory enough for biological experiments.