TRANSCRIPTOMIC PROFILE OF PERIPHERAL WHOLE BLOOD REVEALS NOVEL POTENTIAL DIAGNOSTIC GENE BIOMARKERS OF DEGENERATIVE JOINT DISEASE (OSTEOARTHRITIS) IN GERMAN SHEPHERD DOGS

RUDD GARCES, G.; PERAL GARCÍA, P.; PADULA, GISEL; GIOVAMBATTISTA, G.

Virtual

Conferencia; 38th International Society for Animal Genetics Virtual Conference (2021); 2021

International Society for Animal Genetics

Degenerative joint disease (osteoarthritis) is one of the most common chronic musculoskeletal diseases in human population. Susceptibility to osteoarthritis has been associated with more than 90 quantitative trait loci (QTL). Canine forms of degenerative joint disease are very similar to those in humans and represent a welfare problem in the dog world population. In this study, we Investigated the transcriptomic profile of peripheral whole blood in German shepherd dogs with degenerative joint disease to identify biomarkers. The bulk RNA-seq experiment was performed in a cohort of 12 adult dogs, 5 affected and 7 unaffected. Radiographs in affected dogs revealed severe osteoarthritis in hip and elbow joints. The differential expression analysis showed 688 genes differentially expressed in comparison to the control group (P-value