New and improved synthesis of (±)-4-Bromo-7,8-dimethoxy-isochroman-3-one, a key intermediate for the elaboration of (±)-cis-alpinine and (±)-cis-alpinigenine.

DARÍO A. BIANCHI; TEODORO S. KAUFMAN

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Organic Preparations and Procedures, Inc.

Año: 2004 vol. 36 p. 195 - 199

0030-4948

We report a convenient, altemative and efficient synthesis of bromolactone 3, starting from 2,3-dimethoxytoluene (4), which proceeds through the known glyoxylate 5.