INVESTIGADORES
GAMBERALE Romina
artículos
Título:
Methylation status regulates LPL expression in CLL.
Autor/es:
ABREU CECILIA; MORENO PILAR; PALACIOS FLORENCIA; BORGE MERCEDES; MORANDE PABLO; PEGAZZANO MARÍA; BIANCHI SERGIO; LANDONI ANA INÉS; AGRELO RUBÉN; GIORDANO MIRTA; DIGHIERO GUILLERMO; GAMBERALE ROMINA; GIORDANO MIRTA
Revista:
LEUKEMIA AND LYMPHOMA
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 2013 vol. 54 p. 1844 - 1848
ISSN:
1042-8194
Resumen:
Among different prognostic factors in chronic lymphocytic leukemia
(CLL), we previously demonstrated that lipoprotein lipase (LPL) is
associated with an unmutated immunoglobulin profile and clinical poor
outcome. Despite the usefulness of LPL for CLL prognosis, its functional
role and the molecular mechanism regulating its expression are still
open questions. Interaction of CLL B-cells with the tissue
microenvironment favors disease progression by promoting malignant
B-cell growth. Since tissue methylation can be altered by environmental
factors, we investigated the methylation status of the LPL gene and the
possibility that overexpression could be associated with
microenvironment signals. Our results show that a demethylated state of
the LPL gene is responsible for its anomalous expression in unmutated
CLL cases and that this expression is dependent on microenvironment
signals. Overall, this work proposes that an epigenetic mechanism,
triggered by the microenvironment, regulates LPL expression in CLL
disease.