INVESTIGADORES
GAMBERALE Romina
artículos
Título:
Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia.
Autor/es:
GAMBERALE ROMINA; GEFFNER JORGE; GIORDANO MIRTA
Revista:
LEUKEMIA AND LYMPHOMA
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 2002 vol. 43 p. 251 - 255
ISSN:
1042-8194
Resumen:
The progressive accumulation of B-cell
chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to
resistance to apoptosis, although this can be modulated in vitro by a
variety of cellular and humoral factors (cell-cell, cell-matrix
interactions, cytokines). We have previously reported that IgG immune
complexes (IC) delay B-CLL cell apoptosis through a paracrine mechanism,
which depends on monocytes and NK cells. On the other hand, despite the
fact that IC effectively bind to type II Fc gammaRs expressed on B-CLL
cells, they are unable to deliver transmembrane signals. We speculate
that this lack of responsiveness of resting B-CLL cells to IC could be
overcome by activation. The analysis of this possibility would be
relevant since the presence of circulating IC is a common feature in
B-CLL patients.