INVESTIGADORES
GAMBERALE Romina
artículos
Título:
The impact of extracellular acidosis on dendritic cell function
Autor/es:
VERMEULEN MÓNICA; GAMBERALE ROMINA; TREVANI ANALIA; MARTINEZ DIEGO; CEBALLOS ANA; SABATÉ JUAN; GIORDANO MIRTA; GEFFNER JORGE
Revista:
CRITICAL REVIEWS IN IMMUNOLOGY
Editorial:
BEGELL HOUSE INC
Referencias:
Año: 2004 vol. 24 p. 363 - 384
ISSN:
1040-8401
Resumen:
Dendritic cells (DCs) are the most efficient antigen-presenting cells.
They are activated in the periphery by conserved pathogen molecules and
by inflammatory mediators produced by a variety of cell types in
response to danger signals. It is widely appreciated that inflammatory
responses in peripheral tissues are usually associated with the
development of acidic microenvironments. Surprisingly, there are
relatively few studies directed to analyze the effect of extracellular
acidosis on the immune response. We focus on the influence of
extracellular acidosis on the function of immature DCs. The results
presented here show that acidosis activates DCs. It increases the
acquisition of extracellular antigens for MHC class I-restricted
presentation and the ability of antigen-pulsed DCs to induce both
specific CD8+ CTL and B-cell responses. These findings may have
important implications to our understanding of the mechanisms through
which DCs sense the presence of infection or inflammation in nonlymphoid
tissues.