Luteolin: cyto-genotoxic effects on normal cells

CARIDDI LAURA NOELIA; MONTIRONI IVANA; SABINI MARÍA CAROLA

Luteolin Natural Occurrences, Therapeutics, Applications and Healph Effects

NOVA PUBLISHERS

Lugar: New York; Año: 2015; p. 101 - 107

Luteolin belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. Different studies are focused on their beneficial properties of luteolin and little is known about the damage of this flavone in normal host cells. The studies conducted in order to evaluate the cyto-genotoxic effects of luteolin on normal animal and human cells shown diverse results that reveal that this flavone could have toxic effects depending on diverse factors as concentration, test carried out (in vitro or in vivo), time and mode of administration and type of cell. Because there are many biological activities attributed to luteolin, some of which could be beneficial or detrimental depending on various aspects, further studies are required to ensure the security of this flavonoid for potential future application in a host system.