Effect of goat yogurt administration on bacterial translocation in a model of acute liver injury

CACHI ARIANA; LAZARTE SANDRA; ALVAREZ SUSANA; NUÑEZ DE KAIRUZ MARTHA; SALVA SUSANA; AGÜERO GRACIELA

Tafí del Valle. Tucumán

Jornada; XXI Jornadas Científicas, Asociación de Biología de Tucumán; 2004

Asociación de Biología de Tucumán

In acute liver injury (ALI), bacterial traslocation (BT) World cause the infectious complications. Previously we demonstrated that Lactobacillus casei and Lactobacillus plantarum partially avoid BT and liver damage extent in an experimental model. ALI was induced by intraperitoneal injection of D-galactosamine (DG) in adults BALB/c mice; controls were injected with saline solution. Samples were obtained 6, 12 and 24 hours post-inoculation. Groups of mice were orally administered with goat (GY) and cow (CY) yogurt for 2, 5 and 7 days before injection. BT was evaluated by ganglion, spleen and liver culture. Liver injury was studied by serum GPT and GOT. Serum C reactive protein (CRP) and total and differential leukocyte count were measured. After 7 days of feeding, both yogurts were effective to prevent BT but only CY reduced GOT to normal level. CRP was positive at 12 and 24 hours while leukocytes were not modified. GY administration was effective to avoid BT induced by DG, but it could not normalize serum transaminase levels. Probably BT and trasaminase increase would de events that take place at different times. The effects were dose dependent.