Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

HERRERA MATÍAS; SALVA SUSANA; VILLENA JULIO; BARBIERI NATALIA; ALVAREZ SUSANA

Journal of Functional Foods

International Society for Nutraceuticals and Functional Foods (ISNFF)

Año: 2013 vol. 5 p. 1693 - 1704

1756-4646

The aim of this work was to evaluate the effect of Lactobacillus rhamnosus CRL1505 on blood and bone marrow myeloid cells and their correlation with the resistance against Streptococcus pneumoniae infection of protein-malnourished mice. L. rhamnosus induced the recovery of the bone marrow responsiveness against the infectious challenge through the increase of myeloid progenitors and the mobilization of granulocytes. Repletion of malnourished mice with supplemental L. rhamnosus normalized the number of Gr1+ cells and the balance of Gr1low and Gr1high cells in the bone marrow. This effect in bone marrow increased respiratory immune response and resistance against S. pnumoniae infection, since improved neutrophils recruitment and higher phagocytic activity was observed in probiotic treated mice. This research provides strong evidence of the importance of dietary supplementation with a probiotic lactic acid bacterium to reverse the changes in the homeostasis of the myeloid progenitors in malnourished mice. In a previous work, we found that L. rhamnosus has optimal technological properties, and can be used to produce high quality fermented goat milk. This fact and the present results strongly suggest that this strain could be used in the development of probiotic foods, which would be especially useful for the recovery of immunocompromised hosts.