Effect of RN-301 Immunomodulator on bronchus-associated lymphoid tissue (BALT) in protein depleted rats at weaning

MARÍA GABRIELA MÁRQUEZ; GUSTAVO ADOLFO SOSA; NORA H. SLOBODIANIK; ALEJO FLORÍN-CHRISTENSEN; M ESTELA ROUX

MEDICINA (BUENOS AIRES)

Fundación Revista Medicina

Lugar: Buenos Aires; Año: 1997 vol. 57 p. 428 - 432

0025-7680

It has been previously demonstrated in Wistar rats that severe protein deprivation at weaning, even after refeeding with a 20% casein diet for 21 days, provokes alterations in IgA+ B cell and T cell populations from gut and GALT (gut associated lymphoid tissue) that are reverted by immunomodulator IM-104. In the present report, we investigate the influence of RN-301 (quite similar to IM-104) given by the oral or subcutaneous route during the protein deprivation period, in the seeding of BALT with IgA+ B and CD5+T cells. The immunomodulator RN-301 contains LPS from E. coli and membrane and ribosomal fractions of P. acne. Tissue sections of the lower respiratory tract were studied by immunohistochemistry. The immunomodulator RN-301 administered by the oral route favours the significant increase in the seeding of the BALT lamina propria with IgA+B and CD5+T cells (p