Androgen regulations of cellular events involve in bone perfusion

CAMPELO A.; CUTINI P.; RAUSCHEMBERGER M.B.; MASSHEIMER V.

Congreso; XXIX Reunión Anual de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM); 2012

We studied the effect of testosterone (T) on nitric oxide (NO) production, endothelial cell (EC) migration and VEGF synthesis; key factors for bone perfusion and vascularization. We previously reported that in rat aortic strips 1?20 min treatment with T (0.01?100 nM) significantly increased NO production in a non-gender specific manner. We found that the stimulatory action of T on NO synthesis decreased with age (7.84±0.83 vs 3.82±0.60 nmol NO/mg prot, young vs adult, p