Antitumoral effects of naringenin and its complex with oxidovanadium(IV) on breast cancer cell lines in culture. Albumin binding studies by Fluorescence Spectroscopy

LUCIANA G. NASO , MARÍA S. ISLAS , MARÍA VALCARCEL , CLARISA SALADO , MERITXELL ROURA-FERRER , EVELINA G. FERRER , PATRICIA A. M WILLIAMS

Chascomús

Workshop; 4th Latin American Meeting on Biological Inorganic Chemistry.5th Argentinean Workshop of Bioinorganic Chemistry; 2014

Protective effects on cancer and cardiovascular diseases are associated to phenolic compounds. Among the various types of flavonoids, naringenin (fruits) has been shown to possess antioxidant, anti-inflamatory, antiproliferative and antimutagenic properties, and recent studies suggest that it could be a useful chemoprotective agent. Oxidovanadium(IV)-flavonoids complexes have also demonstrated antiproliferative activities.Taking into account that the breast cancer is the predominant type of cancer in industrialized countries and the second leading cause of deaths in women, we focus our studies in the search of compounds with high selectivity against tumor cells. On the other hand, it is well known that serum albumin is the most important transport protein in plasma and is also capable of binding and transporting metabolites, drugs, dyes and organic compounds. The investigation of the binding of different compounds to albumin becomes important because of their pharmacokinetic and pharmacodynamic behavior.