INVESTIGADORES
HIGA Romina Daniela
artículos
Título:
Pro-oxidant/pro-inflammatory alterations in the offspring's heart of mild diabetic rats are regulated by maternal treatments with a mitochondrial antioxidant
Autor/es:
HIGA R; ROBERTI S; CAPOBIANCO E; FORNES D; WHITE V; JAWERBAUM A
Revista:
REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.)
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 73 p. 269 - 279
ISSN:
0890-6238
Resumen:
Maternal diabetes programs metabolic and cardiovascular diseases in the offspring. Here, we demonstrated increased pro-oxidant/pro-inflammatorymarkers in the heart of 2-day-old offspring of diabetic rats, previous to theinduction of metabolic alterations. At a pre-pubertal stage, sex-dependentchanges were evidenced in the diabetic group, as only males showed increasedglycemia as well as increased lipoperoxidation and concentrations of nitratedproteins, matrix metalloproteinase-9 and peroxisome proliferator activated receptoralpha (PPARalpha) in the heart. Differently, the heart of male and female offspring ofdiabetic rats showed increased levels of connective tissue growth factor (CTGF).Maternal treatments with idebenone, a mitochondrial antioxidant, led toreductions in all the pro-oxidant and pro-inflammatory markers evaluated and inPPARá protein expression in the heart of the offspring of diabetic rats. Theresults of the present study highlight the gender dependence and the role of oxidativestress in the diabetes-induced intrauterine programming of heart alterations.
