Rho GTPases at the crossroad of signaling networks in mammals

JOSÉ WOJNACKI , GONZALO QUASSOLLO , MARÍA-PAZ MARZOLO , AND ALFREDO CÁCERE

Small GTPases

Austin, TX : Landes Bioscience

Lugar: filadelfia; Año: 2014

Microtubule (MT) organization and dynamics downstreamof external cues is crucial for maintaining cellular architectureand the generation of cell asymmetries. In interphase cellsRhoA, Rac, and Cdc42, conspicuous members of the familyof small Rho GTPases, have major roles in modulating MTstability, and hence polarized cell behaviors. However, MTs arenot mere targets of Rho GTPases, but also serve as signalingplatforms coupling MT dynamics to Rho GTPase activation in avariety of cellular conditions. In this article, we review some ofthe key studies describing the reciprocal relationship betweensmall Rho-GTPases and MTs during migration and polarization.