Manufacturing Techniques for Nanoparticles in Drug Delivery

PAREDES, ALEJANDRO J.; REAL, DANIEL A.; FORMICA, MARÍA L.; PICCHIO, MATÍAS L.

Drug Delivery Using Nanomaterials

Taylor and Francis

Año: 2022; p. 1 - 26

Nanotechnology has become an important tool for the development of novel productsfor prevention, treatment, and diagnosis of multiple acute and chronic disorders.Nanoparticle-based drug delivery systems are currently one of the most valuablestrategies for addressing low solubility and tissue selectivity in drug delivery.Nanoparticles (NPs) can increase the solubility and permeation of drugs and producetheir accumulation in target tissues, ultimately leading to improved therapeutic results(Pakzad et al., 2020). NPs present sizes between 1 and 1000 nm, and the activepharmaceutical ingredient can be adsorbed, encapsulated, trapped, or covalentlybound to the NPs matrix or surface. Moreover, NPs may also be formed only by thesolid drug, as in nanosuspensions, leading to a greater drug loading capacity.When the active is loaded into nanocarriers, a sustained release is achievable,enabling the use of these NPs to develop long-acting formulations. Moreover, encapsulatingthe drug into nanocarriers can protect it from degradation in the body, i.e.,by a low pH in the gastrointestinal tract or by the presence of plasmatic enzymes(Jiang et al., 2018; Lin et al., 2015; Weng et al., 2017). However, NPs formulation is acomplex state-of-the-art that combines the selection of suitable excipients and techniques.The comprehension of this vast field is fundamental for pharmaceutical scientistsand pharmacy students. Consequently, the present primary goal of this chapteris to discuss different manufacturing techniques for NPs with drug delivery purposes.