INVESTIGADORES
GARCIA Manuela Emilia
artículos
Título:
Antiproliferative Activity of Withanolides Derivatives from Jaborosa cabrerae and J. reflexa. Chemotaxonomical considerations.
Autor/es:
MANUELA E. GARCIA; GLORIA BARBOZA; JUAN CARLOS OBERTI; JOSE MANUEL PADRÓN; VIVIANA NICOTRA; ANA ESTEVEZ- BRAUN; ANGEL GUTIERREZ RAVELO; CARLA RÍOS -LUCI
Revista:
PHYTOCHEMISTRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Washington; Año: 2012 vol. 76 p. 150 - 157
ISSN:
0031-9422
Resumen:
Three withanolides were isolated from the aerial parts of Jaborosa reflexa Phil. Jaborosa cabrerae Barboza yielded five sativolide withanolides (including jaborosalactones R, S, 38, and 39) and two trechonolide withanolides epimeric at C-23 (trechonolide A and jaborosalactone 32). In addition, five derivatives were obtained by chemical derivatization of jaborosalactone 38, and all compounds were fully characterized by 1D and 2D NMR spectroscopic studies. The in vitro antiproliferative activities of the major natural withanolides and the semisynthetic derivatives were examined against HBL-100, HeLa, SW1573, T-47D, and WiDr human solid tumor cancer cell lines. Some chemotaxonomic considerations are discussed.
