Biocatalysed concurrent production of enantioenriched compounds through parallel interconnected kinetic asymmetric transformations

ANA RIOZ-MARTÍNEZ; FABRICIO R. BISOGNO; CRISTINA RODRÍGUEZ; GONZALO DE GONZALO; IVÁN LAVANDERA; DANIEL E. TORRES PAZMIÑO; MARCO W. FRAAIJE; VICENTE GOTOR

ORGANIC & BIOMOLECULAR CHEMISTRY

ROYAL SOC CHEMISTRY

Año: 2010 vol. 8 p. 1431 - 1437

1477-0520

Parallel interconnected kinetic asymmetric transformations were performed in order to obtain enantioenriched derivatives starting from a set of racemic or prochiral compounds. Thus, in a one-potone-pot reaction using two redox biocatalysts (a BVMO and an ADH) and a catalytic amount of cofactor that acts as a mediator, enantioenriched ketones, sulfoxides, and sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.