INVESTIGADORES
BISOGNO Fabricio Roman
artículos
Título:
Structure-Antifungal Activity Relationship of Cinnamic Acid Derivatives
Autor/es:
FABRICIO R. BISOGNO; MARÍA LAURA MASCOTTI; CECILIA SANCHEZ; FRANCISCO GARIBOTTO; FERNANDO GIANNINI; MARCELA KURINA-SANZ; RICARDO ENRIZ
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2007 vol. 55 p. 10635 - 10640
ISSN:
0021-8561
Resumen:
A structure-antifungal activity relationship (SAR) study of 22 related cinnamic acid derivatives was
carried out. Attention was focused on the antifungal activities exhibited against Aspergillus flavus,-antifungal activity relationship (SAR) study of 22 related cinnamic acid derivatives was
carried out. Attention was focused on the antifungal activities exhibited against Aspergillus flavus,Aspergillus flavus,
Aspergillus terreus, and Aspergillus niger. (E)-3-(4-Methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic acid
(16) exhibited antifungal activity against A. niger, comparable to that of miconazole and a significant
antifungal effect against A. flavus and A. terreus as well. A structureactivity relationship (SAR) study
of related cinnamic acid derivatives has allowed a model to be proposed for the recognition of the
minimal structural requirements for the antifungal effect in this series., and Aspergillus niger. (E)-3-(4-Methoxy-3-(3-methylbut-2-enyl)phenyl)acrylic acid
(16) exhibited antifungal activity against A. niger, comparable to that of miconazole and a significant
antifungal effect against A. flavus and A. terreus as well. A structureactivity relationship (SAR) study
of related cinnamic acid derivatives has allowed a model to be proposed for the recognition of the
minimal structural requirements for the antifungal effect in this series.16) exhibited antifungal activity against A. niger, comparable to that of miconazole and a significant
antifungal effect against A. flavus and A. terreus as well. A structureactivity relationship (SAR) study
of related cinnamic acid derivatives has allowed a model to be proposed for the recognition of the
minimal structural requirements for the antifungal effect in this series.A. flavus and A. terreus as well. A structureactivity relationship (SAR) study
of related cinnamic acid derivatives has allowed a model to be proposed for the recognition of the
minimal structural requirements for the antifungal effect in this series.