INVESTIGADORES
GRUBER Nadia
artículos
Título:
1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines
Autor/es:
JIMENA E. DÍAZ; NADIA GRUBER; LILIANA R. ORELLI
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 52 p. 6443 - 6445
ISSN:
0040-4039
Resumen:
In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3- diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N0-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in solvent-free conditions. Precursors 2 were prepared by selective functionalization of N-arylcadaverines 3.
