Encapsulation of Curcumin in Pristine and Glucosylated Poly(ethylene oxide)-b-poly (propylene oxide) Polymeric Micelles Improves the Antitumoral Efficacy In Vitro and the Uptake In Vivo

LECOT N.; GLISONI R.J.; ODDONE N.; FERNANDEZ M.; GAMBINI J.P. ; CABRAL P.; SOSNIK A.

Cancún, México

Congreso; International Material Research Congress (IMRC); 2015

Materials Research Society

Curcumin (CUR), a polyphenolic anti-inflammatory, antioxidant, anti-proliferative and antiangiogenic compound derived from Curcuma longa has gained interest in the therapy of different disease, including cancer (1). However, its poor aqueous solubility challenges the oral and parenteral administration (2). The goal of this work was to explore the encapsulation of CUR into polymeric micelles (PMs) of made of pristine poly(ethylene oxide)-b-poly(propylene oxide) block copolymers (PEO-PPO) and their glucosylated derivatives and evaluate their antitumoral activity in vitro employing a murine mammary cell line (3).