INVESTIGADORES
GLISONI Romina Julieta
congresos y reuniones científicas
Título:
Molecular dynamics study of 1-indanone thiosemicarbazones/hydroxypropyl-β- cyclodextrin complexes formation: evidences of a cooperative effect
Autor/es:
M. FLORENCIA MARTINI; R. GLISONI; A. MOGLIONI; A. SOSNIK; M. PICKHOLZ
Lugar:
Carlos Paz, Córdoba
Reunión:
Congreso; XLII Reunión Anual de la Sociedad Argentina de Biofísica; 2013
Institución organizadora:
Sociedad Argentina de Biofísica
Resumen:
Among the thiosemicarbazones (TSCs) have been reported varied activities: antineoplastic, antibacterial, antifungal, antiprotozoal and antiviral. However, TSCs display extremely low aqueous solubility and a relatively high tendency to self-aggregate in water [1,2]. Cyclodextrins (CDs) are macrocyclic oligosaccharides that combine a hydrophobic nano-sized cavity with a hydrophilic surface. The cavity enables the partial or total incorporation of lipophilic molecules. In this molecular study, we have analyzed the stabilization of inclusion complexes formed between hidroxy-propyl--cyclodextrin (HPCD) and two TSC molecules: 1-indanone TSC (1TSC) and 5,6-dimethoxy-1-indanone TSC (2TSC).
