EPIGENETIC ASSYMETRY IN BREAST TUMORS OF DIFFERENT SIDES OF THE BODY

CAMPOY, EMANUEL MARTIN; BRANHAM, MARIA TERESITA; LAURITO, SERGIO; URRUTIA, GUILLERMO; MATHINSON, ANGELA; OROZCO, JAVIER; URRUTIA, RAUL; MAYORGA, LUIS; ROQUÉ, MARÍA

Holderness

Conferencia; Gordon Conference: ?Epigenetics?; 2017

Gordon Research Conference

During the breast tumorigenic process, epigenetic alterations accumulate in tumor cells as an adaptive response to environmental challenges. In this study we established the methylation profile of 96 CpG sites located within54 cancer genes of 51 invasive breast human tumors so as to infer their potential impact on six Cancer Hallmarks (CH): i.e. sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, induction ofangiogenesis, genome instability and invasion and metastasis. Insilico expression data of the studied genes was also analyzed. By converting methylation or expression profiles in terms of Cancer Hallmarks, it uncovered veiledassociations with clinical features. In adition we also studied the methylation profile of 54 tumor supressor genes in xenograft denveloped by inoculation of MDA-MB231 cells in right and left mammary glands of nude mice.