Gut permeability and glucose absorption are affected at early stages of graft rejection in a small bowel transplant rat model

STRINGA, P; ROMANIN, D; LAUSADA, N; PAPA GOBBI, R; ZANUZZI, C; MARTÍN, P; ABATE, JC; CAVANNE, A; ARNAL, N; VECCHIO, L; MILESI, V; PORTIANSKY, E; GONDOLESI, G; RUMBO, M

Transplantation Direct

Wolters Kluwer

Año: 2017 vol. 3

2373-8731

Intestinal transplantation (ITx) faces many challenges, secondary to thecomplexity of the surgical technique, to the multiple immunological reactionsthat occur during and after engraftment and to the necessity of rigorousfollow-up for early detection of rejection processes(1). Rodent models of small bowel transplantation (SBTx) were used toprovide evidence for intervention strategies, understand immunological featuresof ITx as well as to improve our knowledge of ITx biology(2). By far, rat ITx models were the most extensively used due to technicalrefinement and availability of different strains(3). Orthotopic (OITx) and heterotopic (HITx) variants of ITx can be used,each of them allowing the evaluation of different aspects of the process(4) . Despite HITx models do not reproduce the physiological anatomy of anorthotopic procedure, they are commonly used to study immunological reactions,such as graft versus host disease and rejection. HITx has higher survival rate,involves a simpler technique and allowing serial sampling of the graft. Thoseare major reasons for selecting this model.