Celiac Disease: Historical Standpoint, New Perspectives of Treatments and Contemporary Research Techniques.

BENEDINI LUCIANO; GONZALEZ VIDAL NOELIA; GONZALEZ ALEJANDRA

CURRENT PROTEIN AND PEPTIDE SCIENCE

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2018 vol. 19

1389-2037

Celiac disease (CD) is an inflammatory syndrome thataffects mainly the intestine, but also other organs. This ailment is alsoaffected by the physicochemical behavior of gluten as such. From the medicalstandpoint, this pathology results from a combination of genetic andenvironmental factors. At the same time, gliadin (the alcohol-soluble fractionof gluten) along with other related oligomers, such as 33-gliadin, present highimmunogenicity and areresponsible for triggering of this disease. Within CDcharacterization, there are mainly two different approaches to carry out thisstudy; one focuses on its chronic phase, while the other deals with its initialstages. Although the chronic phase of CD has been well characterized, theinitiation of the inflammatory process is still unclear. As this process isapparently related to the aggregation of the oligomers involved in CD, theinitiation of the disease could be explained by means of clarifying theirself-assembly behavior. Thus, this work addresses the clinical explanation,within the chronic approach, attempting to combine it with the physicochemicaltechniques used for characterization of proteins aggregates as well.