INVESTIGADORES
BENEDINI Luciano Alejandro
artículos
Título:
Colloidal properties of amiodarone in water at low concentration,
Autor/es:
LUCIANO BENEDINI, PAULA V. MESSINA, RUBEN H. MANZO, DANIEL A. ALLEMANDI,; SANTIAGO D. PALMA, ERICA P. SCHULZ, MARISA A. FRECHERO, PABLO C. SCHULZ
Revista:
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2010 vol. 342 p. 407 - 414
ISSN:
0021-9797
Resumen:
ABSTRACT
Amiodarone aqueous systems at concentrations C £ 3 mg/mL were studied with
different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity,
polarizing microscopy, computational simulation, electron microscopy and fluorescence
at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity,
polarizing microscopy, computational simulation, electron microscopy and fluorescence
at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
£ 3 mg/mL were studied with
different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity,
polarizing microscopy, computational simulation, electron microscopy and fluorescence
at various temperatures. The Krafft point (TK = 70.6 ºC) was determined. A partial
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TK
K = 70.6 ºC) was determined. A partial
phase diagram was plotted showing the critical micelle concentration (CMC)
dependence on temperature, the solubility and a transition between a coacervate and an
unstable gel below TK as a function of temperature. The nature of aggregates below TKK as a function of temperature. The nature of aggregates below TK
at different concentrations was determined. Micellization is an entropy-driven process
which is probably caused by a strong dehydration of the amiodarone backbone on
micellization. CMC, micelle aggregation number and TK given in earlier literature were
misinterpreted in the original articles and are re-interpreted in this work.
misinterpreted in the original articles and are re-interpreted in this work.
K given in earlier literature were
misinterpreted in the original articles and are re-interpreted in this work.