Relevance and Bio-Catalytic Strategies for the Kinetic Resolution of Ketoprofen towards Dexketoprofen

MARÍA V. TOLEDO; LAURA E. BRIAND

CRITICAL REVIEWS IN BIOTECHNOLOGY

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2018 vol. 38 p. 778 - 800

0738-8551

This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called ?chiral switch? inthe pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. 32In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented. In this context, the biocatalysts, acyl-acceptors (alcohols), reaction conditions, conversion, enantiomeric excess and enantiomeric ratio among others are discussed.Moreover, the investigations concerning scaling up processes in order to obtain an optically pure enantiomer of the profen are presented. Finally some guidelines about perspectives of the technology and research opportunities are given.