Dose-response characterization of gadolinium-infused polymer PAGAT dosimetry aimed at dose enhancement assessment.

M. SANTIBÁÑEZ; Y. GUILLÉN; D. CHACÓN; R. FIGUEROA; M. VALENTE

Santo Domingo

Simposio; ISSSD 2017 - International Symposium of Solid State Dosimetry; 2017

Univ. Aut. Sto Domingo & Univ. Aut. Méx

Nowadays, infusion of high atomic number elements within biological tissue represents one of the most promising mechanisms aimed at imaging and therapeutic medical tasks, like tumor targeting, real-time monitoring and local dose enhancement. It is well known that Gadolinium has proven to be an excellent contrast agent for traditional absorption contrast medical imaging. However, Gd is being considered for different medical tasks regarding local dose enhancement, as preliminary reported for brain tumors treatment [1]. This work reports on the effects of infusing PAGAT [2] polymer gel dosimeters with gadolinium aimed at obtaining an integral stable dosimetry system capable of suitable mixed field dose decomposition in order to assess therapeutic local dose enhancement due to the selective uptake of high atomic number elements, such as Gd, in biological tissues. In this context, capability to elaborate stable and still dosimetric reactive solution is the first step to accomplish the purposed goal of achieving reliable and accurate measurements of local dose enhancement due to Gd presence. A novel dosimetry system was prepared following similar synthesis as for PAGAT dosimeter, but including suitable adaptations to add Gd-based solutions (Omniscan®) obtaining a final stable material whose dose-response was carefully characterized, along with its chemical properties.