3D dose and TCP distribution for radionuclide therapy in nuclear medicine

M. VALENTE; F. MALANO; P. PÉREZ

Santiago

Congreso; VIII Latin American Symposium on Nuclear Physics and Applications; 2009

AMERICAN INSTITUTE OF PHYSICS

A common feature to any radiant therapy is that lesion and health tissue dosimetry provides relevant information for treatment optimization along with dose-efficacy and dosecomplication correlation studies. Nowadays, different radionuclide therapies are commonly available, assessing both systemic and loco-regional approach and using different alfa-, beta- and gamma-emitting isotopes and binding molecules. It is well established, that specific dosimetric approaches become necessary according to each therapy modality. Sometimes, observed activity distribution can be satisfactory represented by simple geometrical models. However, Monte Carlo techniques are capable of better approaches, therefore becoming sometimes the only way to get dosimetric data since the patient-specific situation can not be adequately represented by conventional dosimetry techniques. Therefore, due to strong limitations of traditional and standard methods, this work concentrates on the development of a dedicated and novel calculation system in order to assess the dose distribution within the irradiated patient. However, physical dose may not be enough information in order to establish real deterministic biological/metabolic effects; therefore complementary radiobiological models have been suitably introduced with the aim of performing realistic 3D dose as well as corresponding Tumor Control Probability distribution calculation.