Dose Point Kernel calculation and modelling with nuclear medicine dosimetry purposes

IGNACIO SCARINCI; MAURO VALENTE; PEDRO PÉREZ

MONTEVIDEO

Congreso; X - LATIN AMERICAN SYMPOSIUM OF NUCLEAR PHYSICS AND APPLICATIONS; 2013

Monoclonal labeled antibodies administration with radioimmunotherapy purposes in nu-clear medicine procedures is performed by depositing specific radiactivity concentrationson tumoral regions with the aim of hurt tumoral tissue. Kinetic characteristics of thisantibodies produce a non-uniform activity distribution over the patient body and, inmost of cases with dosimetric purposes, it is assumed uniformly to simplify quantificationon internal dosimetry. Finally, its produce a decrease on the dosimetry calculationpresicion involved on an oncologic treatment [1].Treatment planification requires an estimation of the radionuclide?s delivered dosedistribution that can be approximated by numeric or analytic methods [2]. Numerically,it can be estimated through Monte Carlo methods; while analitically, it can be calculatedby an activity distribution convolution using Dose Point Kernels [3].Actually, almost all of the used calculations in treatment planifications in clinical situa-tions are performed by a simplification of the Boltzmann radiation transport equation,taking into account infinite homogeneous media and using the linearity principle. MonteCarlo method provides, other hand, the calculation capacity and presicion that can notbe achieved by analytic approximations. Actual technologic advances allow high dataprocessing and calculus capacity, so Monte Carlo simulations result in an important toolfor the radiation transport study over soft tissues[4].This work is focused on the utilization of the Monte Carlo method with the aim ofperforming Dose Point Kernels calculations over complex systems that involve biologicmedia in finite dimensions. This precisely results will be used to perform an hybriddose delivery calculation considering a real activity distribution as a non-homogeneouskernels distribution, in a patient-specific media distribution[5], for its addition to a novelcalculation system developed with nuclear medicine dosimetry purposes.