INVESTIGADORES
VALENTE Mauro Andres
congresos y reuniones científicas
Título:
3D dose and TCP distribution for radionuclide therapy in nuclear medicine
Autor/es:
M. VALENTE; F. MALANO; P. PEREZ
Lugar:
Santiago
Reunión:
Congreso; VIII latin american Symposium on nuclear Physics and Applications; 2009
Institución organizadora:
CLAF Universidad de Chile
Resumen:
A common feature to any radiant therapy is that lesion and health tissue dosimetry
provides relevant information for treatment optimization along with dose-efficacy and dose-
complication correlation studies. Nowadays, different radionuclide therapies are commonly
available, assessing both systemic and loco-regional approach and using different alfa-, beta- and
gamma-emitting isotopes and binding molecules. It is well established, that specific dosimetric
approaches become necessary according to each therapy modality. Sometimes, observed activity
distribution can be satisfactory represented by simple geometrical models. However, Monte
Carlo techniques are capable of better approaches, therefore becoming sometimes the only way
to get dosimetric data since the patient-specific situation can not be adequately represented by
conventional dosimetry techniques. Therefore, due to strong limitations of traditional and
standard methods, this work concentrates on the development of a dedicated and novel
calculation system in order to assess the dose distribution within the irradiated patient. However,
physical dose may not be enough information in order to establish real deterministic
biological/metabolic effects; therefore complementary radiobiological models have been suitably
introduced with the aim of performing realistic 3D dose as well as corresponding Tumor Control
Probability distribution calculation.