OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

R. FIGUEROA; M. VALENTE; J. GUARDA; J. LEIVA; E. QUILAGUILQUE; B. CASANELLI; F. LEYTON

X-RAY SPECTROMETRY

JOHN WILEY & SONS LTD

Lugar: LOndres; Año: 2021

0049-8246

A novel and suitable energy-dispersive X-ray fluorescent (EDXRF) device, currently at the prototype stage, the Project OXIRIS (Orthovoltage X-Ray?InducedRadiation System), is presented for the simultaneous detection and treatmentof cancer diseases. Monte Carlo simulation and experimental results of EDXRFsignals from a small deep artificial tumor consisting of a solution of goldnanoparticles bio-targeted and immersed in a tissue-bioequivalent matrix arepresented and compared. Briefly, the device consists of a dynamic orthovoltageX-ray fluence concentration coupled to confocal with an EDXRF system alongwith a sample holder for 3D scanning; all integrated and controlled by a dedicated software capable of controlling the whole operation functionalities: theX-ray source, the rotating arm, the sample holder, and the detection system.The software also includes dedicated subroutines for X-ray fluorescent spectraprocessing to correlate K-lines signal at each acquisition position with thecorresponding high atomic number elements´ concentration to produce a 3Ddistribution according to the user-defined grid. The confocal configurationensures that the detected signal comes exclusively from the excited volume asdefined by the bulk of the focal spot. Hence, the 3D image is achieved by scanning the sample holder through the movement of the sample-carrier stretchermoved by step motors in the 3 coordinated axes. The feasibility of the proposedmethodology and the design of the prototype have been successfully demonstrated experimentally, targeting gold nanoparticles in water-equivalentphantoms.