Dosimetry of tumor targeting imaging by convergent X-ray beam as compared with nuclear medicine

FIGUEROA, R.; GUARDA, J.; LEIVA, J.; MALANO, F.; VALENTE, M.

APPLIED RADIATION AND ISOTOPES

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2021 vol. 167

0969-8043

During decades nuclear medicine procedures, based on radiolabeled agents, have proved to be efficient for diseases diagnosis and treatment. Radiation emerging from patient is detected aimed at localizing radiotracer distribution that is further correlated with biochemical/metabolic physiological processes. However, a signifi- cant drawback associated with current nuclear medicine procedures implementing radionuclide infusion regards to the inherent absorbed dose as well as radiopharmaceuticals? production, storage and elimination from patient body, thus representing a risk at patient and public health level.In the recent years, alternative methods have been proposed to reduce/eliminate radionuclides in some nu- clear medicine procedures. The combination of high atomic number nanoparticles infused within patient body with incident X-ray beam, like tumor targeting and treatment, appears as a potential alternative method capable of theranostics. The process is based on inducing X-ray fluorescence and secondary electrons emission in high atomic number nanoparticles by means of excitation with an external X-ray beam, avoiding employing radio- active substances.The present work reports on the dosimetry performance of both methods, comparing whenever the external convergent X-ray beam alternative may involve less or larger radiation dose levels, according to comparable signal/image quality during the procedure. To this aim, a simplified theoretical model is proposed and associated Monte Carlo simulations are performed in order to compare typical case of nuclear medicine imaging with potential performance of an innovative method, called OXIRIS (Orthovoltage X-ray Induced Radiation and In- tegrated System), based on convergent X-ray beam exciting high atomic number nanoparticles infused in patient.The obtained results support the proposed alternative method?s feasibility, once demonstrated that patient absorbed dose levels are relative similar to those currently used by nuclear medicine procedures, whereas dose to targeted region (tumor) are significantly higher, which may be useful for treatment purposes.