Targeted radionuclide therapy: frontiers in theranostics

GALLIVANONE F.; VALENTE M.; SAVI A.; CANEVARI C.; CASTIGLIONI I.

FRONTIERS IN BIOSCIENCE-LANDMARK

FRONTIERS IN BIOSCIENCE INC

Lugar: Albertson, NY, USA; Año: 2017 vol. 22 p. 1750 - 1759

1093-9946

p { margin-bottom: 0.25cm; line-height: 120%; }The concept oftargeted radionuclide therapy (TRT) relies on the use of injectednuclear medicine as treating agents, targeted at the cellular ormolecular level. The growth of the interest in TRT was stimulated bythe advances in radionuclide production and labeling as well as bythe improvement in the knowledge of appropriate and specificmolecular targets. In recent years, different studies on TRT werefocused on the evaluation of radionuclide compounds able to combineimaging of the disease with TRT, in a theranostic approach. Thisapproach is of particular interest towards the personalization oftreatments, allowing both the baseline characterization ofoncological pathologies and treatment optimization by correctdosimetric calculation as well as therapy monitoring. This paperpresents a review of recent literature on TRT, with a particularfocus on clinical applications promoting such a theranostic approach,showing the impact of the synergy of diagnostic imaging andtherapeutics.