Adiponectin predicts MMP-2 activity independently of obesity.

MIKSZTOWICZ V ; FERNANDEZ MACHULSKY N; LUCERO D; FASSIO E; SCHREIER L; BERG G

Eur J Clin Invest

Wiley

Año: 2014 vol. 44 p. 951 - 957

1365-2362

Background Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, have been identified in atherosclerotic plaques and have been directly associated with plaque remodelling and vulnerability. Cardiovascular disease is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflammatory markers, such as adiponectin and C-reactive protein (CRP). Our aim was to evaluate the impact of both proteins on MMP-2 and MMP-9 behaviour in individuals with IR. Materials and methods Plasma MMP-2 and MMP-9 activity, adiponectin and hs-CRP concentration and lipoprotein profile were determined in 52 patients with metabolic syndrome (MS) and 27 controls. Results Patients with MS presented significantly higher MMP-2 activity than controls: 095 012 vs.077 015 relative units (RU) (P < 0001), while MMP-9 activity was not detectable. MMP-2 activity decreasedacross quartiles of adiponectin, being significantly reduced in individuals with the highest levels of adiponectin incompared with the lowest levels (075 017 vs. 093 009 RU, P < 0005). This difference persisted sig-nificant after adjusting by obesity markers. MMP-2 activity was significantly increased in individuals with thehighest levels (G3) compared with those with the lowest levels (G1) of hs-CRP (094 012 vs. 086 012,P = 0041)Conclusion In this study, we observed that adiponectin levels predicted MMP-2 plasma activity independentlyof obesity. This finding suggests that the inflammatory process, associated with the highest CVD risk, would beinvolved in MMPs vascular production.