Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity.

MIKSZTOWICZ V; SCHREIER L; MCCOY M; LUCERO D; FASSIO E; BILLHEIMER J; RADER DJ; BERG G

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 2014 vol. 34 p. 669 - 675

1079-5642

Objective?To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma ofsubjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins.Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete theanalyses of SN1 lipolytic enzymes in the same patient.Approach and Results?Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. Atrend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weightgroup (P=0.009) and was negatively associated with high-density lipoprotein?cholesterol (P=0.014 and P=0.005) andapolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, wasincreased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein?cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein?cholesterol (P=0.021)in control group. LPL was decreased in MS (P