Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

GAGLIARDI JA ; MACIEL N; CASTELLANO JL; MASOLI O; MIKSZTOWICZ V; BERG G; BERMEJO E; LAZZARI M; GELPI RJ

THROMBOSIS RESEARCH

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 137 p. 92 - 96

0049-3848

Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercisetest on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation inplasma levels of VEGF in chronic coronary patients.Methods: 21 patients b75 years with chronic stable coronary artery disease were included. All patientsunderwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group(11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standardtreatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three monthsduring follow-up.Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significantincrease in VEGF levels compared to those measured immediately after exercise. All patients showed a decreasein the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation betweenchange of EPC and VEGF between the baseline and 1 month.Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels ofEPC. This association was independent of the onset of ischemia in the perfusion study.