SHORT-TERM FEVER-RANGE HYPERTHERMIA MODULATES ANTIBACTERIAL AND PRO-INFLAMMATORY NEUTROPHIL RESPONSES

KEITELMAN IA; SABBIONE F; SHIROMIZU CM; GIAI C; FUENTES F; ROSSO D; LEDO C; MIGLIO RODRÍGUEZ M; GUZMAN M; GEFFNER JR; GALLETTI J; JANCIC C; GÓMEZ MI; TREVANI AS

Tucumán

Congreso; LXVII Reunión Anual de la Sociedad Argentina de Inmunología; 2019

Sociedad Argentina de Inmunología

Fever is a physiological and evolutionary conserved response to infection and injury that takesplace as a consequence of the temporary resetting of the body?s thermostatic set point. Duringthe course of fever, neutrophils become exposed to temperatures between 38°C-41°C. We havepreviously determined that short-term fever-range hyperthermia (STFRH; 1h at 39.5°C)promotes NETosis when neutrophils are exposed to PMA and the Gram-negative bacteria P.aeruginosa. To further investigate STFRH impact, neutrophils isolated from healthy donorswere incubated at 37°C or 39.5°C for 1h, and then challenged with P. aeruginosa PAO-1 at 37°Cfor different times. Then, the impact of temperature on different neutrophil functions wasdetermined. While STFRH moderately reduced P. aeruginosa-GFP phagocytosis (*p