RESOLVIN D5 PRESENT IN TUBERCULOUS PLEURAL EFFUSIONS PROMOTES A PRO-RESOLVING PROFILE IN MACROPHAGES BY IMPAIRINGHIF1-α IN RESPONSE TO MYCOBACTERIUM TUBERCULOSIS

JOAQUINA BARROS; MAIO M; MARÍN FRANCO JL; SABBIONE F; FEDERICO FUENTES; PALMERO D; ARAGONE X; ARGUELLO, R; LAYRE, EMILIE; LUGO-VILLARINO G; NEYROLLES O; ERREA A; CHRISTEL VEROLLET; BALBOA L

San Luis

Congreso; LXXI Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2023

Tuberculosis, caused by Mycobacterium tuberculosis, remains a major globalhealth problem accounting for millions of deaths annually. Previously, we foundthat proinflammatory (M1) macrophages exposed to the acellular fraction ofpleural effusionsfrom TB patients (TB-PE) displayed a reduced glycolytic activityby targeting the hypoxia- inducible factor (HIF)-1α expression, and ultimatelyimpairing the resistance to infection. Such properties were driven bypolyunsaturated fatty acid metabolites within TB-PE fractions. In particular, wefound that the abundances of 18-HEPE, 7(R)-Maresin 1, Protectin Dx andResolvin D5 correlated with the inhibition of M1 macrophages’ glycolysis(p