INVESTIGADORES
SPETALE Flavio Ezequiel
congresos y reuniones científicas
Título:
GO Function prediction by True Path Rule
Autor/es:
BULACIO PILAR; SPETALE FLAVIO EZEQUIEL; ANGELONE LAURA; TAPIA ELIZABETH
Lugar:
Oro Verde
Reunión:
Congreso; 3er. Congreso Argentino de Bioinformática y Biología Computacional; 2012
Resumen:
Protein function prediction is an important problem in bioinformatics research. Useful tools have been developed to identify similar sequences regarding their corresponding annotation database. But when nosimilar sequences can be found, carefully designed data mining techniques may provide an important clue to protein function prediction. In particular, hierarchical classification methods like the True Path Rule (TPR) can take into account the relationships among protein functions defined on Gene Ontology (GO). This GO structure influences in two points: i) In the design of the training datasets for machine-learning classifiers, and ii) In the global function prediction since a sequence may belong to multiple classes.
