INVESTIGADORES
SPETALE Flavio Ezequiel
congresos y reuniones científicas
Título:
Automatic GO annotation of gene products in SARS-CoV-2
Autor/es:
SPETALE FLAVIO EZEQUIEL; ELIZABETH CHIACCHIERA; IGLESIAS NATALIA; TAPIA ELIZABETH; PONCE SERGIO; BULACIO PILAR
Lugar:
Capita; Federeal
Reunión:
Congreso; Congreso SABI 2023; 2023
Resumen:
Genetic annotation is critical to understanding how genes work. This is especially important when annotating genes in SARS-CoV-2 virus to develop treatments and vaccines. Such as the spike (S) protein gene, which helps the virus enter host cells, and others related replication and release. Genetic annotation involves both experimental and computational methods. We predict on Gene Ontology (GO) that organizes genes into categories: Molecular Function (MF), Biological Process (BP), and Cellular Component (CC). However, for viruses with high variability and high mutation rates, we need machine learning methods to predict gene functions from sequences. In this context, we introduce the FGGA (Factor Graph GO Annotation) software to annotate SARS-CoV-2 genes, which only requires a set of well-annotated viral sequences for its training.
