The Hamster Cheek Pouch (HCP) as an Experimental Model of Oral Cancer for BNCT: Biodistribution and Pharmacokinetics of BPA

KREIMANN E; ITOIZ ME; DAGROSA MA; GARAVAGLIA RN; FARIAS S; BATISTONI D; SCHWINT AE

Osaka, JAPAN

Congreso; Ninth International Symposium on Neutron Capture Therapy for Cancer; 2000

INTERNATIONAL SOCIETY FOR NEUTRON CAPTURE THERAPY

We propose and validate the HCP model of oral cancer for BNCT studies. This model serves to explore new applications of the technique, study the biology of BNCT and assess Boron uptake in clinically relevant oral tissues. Tumors are induced by a process that mimics spontaneous malignant transformation instead of by the growth of implanted tumor cells. Syrian hamsters were submitted to tumor induction with a chemical carcinogenesis protocol and then used for biodistribution and pharmacokinetic studies of BPA. The data reveal selective uptake by tumor and, to a lesser degree, by precancerous tissue. Boron concentration in oral tissues and skin was higher than in blood, an issue of clinical relevance given that these tissues may be dose-limiting. Absolute and relative values of Boron concentration would be potentially therapeutic. Boron concentration exhibited a linear relationship with percentage of viable tissue in HCP tumors. The HCP model would provide a novel, contributory approach to BNCT research.