GLYPHOSATE BASED HERBICIDE EXPOSURE MAY EXACERBATE ENDOMETRIAL HYPERPLASIA INDUCED BY CAFETERIA DIET IN ADULT RATS

ZANARDI, MARÍA V.; GASTIAZORO, MARÍA P.; LORENZ, VIRGINIA; GUERRERO SCHIMPF, MARLISE; ALMIRÓN, AILÍN; MILESI, MARÍA M.; ZIERAU, OLIVER; VARAYOUD, JORGELINA; DURANDO, MILENA

Modalidad Virtual

Congreso; Reunión de Sociedades de Biociencias 2021, LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2021

Sociedad Argentina de Investigación Clínica (SAIC)

Many lifestyle factors can predispose to the development of endometrial carcinoma (EC). Previously, in rats, we detected that: a) cafeteria diet (CAF) induced endometrial hyperplasia (EH), a precursor lesion of EC; b) exposure to glyphosate-based herbicide (GBH) altered uterine development causing EH and increased cell proliferation. In the present work we sought to evaluate whether the exposure to a low-dose of a GBH plus CAF diet might enhance the uterine morphological alterations induced by CAF diet alone. Female Wistar rats were fed from postnatal day 21 (PND21) until PND240 with: chow diet (CON) or CAF. At PND140 one group of rats feed with CAF also received GBH through food, yielding 3 experimental groups: CON; CAF; CAF+GBH. Rats were sacrificed at PND240 and serum, fat depots, and uterine samples were obtained. Data were analyzed by Kruskal?Wallis followed by Mann-Whitney post-test (p