High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats

SANTIANO F; SASSO CV; ZYLA L; BRUNA F; CAMPO VERDE ARBOCCO F; PISTONE CREYDT V; LÓPEZ FONTANA C; CARÓN RW

Biomedical Journal of Scientific & Technical Research

Biomedical Research Group (EEUU, Westchester)

Lugar: Westchester; Año: 2019 vol. 12

2574-1241

Environmental factors in early life have a strong implication on the development of diseases in adult life. Nutritional changes during perinatal life can modify the susceptibility to develop breast carcinoma. In this report, we studied the influence of a diet high in saturated fat in the development of breast cancer, in rats that maintained a differential milk intake during their lactation period. We also analysed the possible mechanisms involved in tumor development. We compared mammary carcinogenesis in Sprague-Dawley adult rats, grown-up in litters of 3 (L3) or 8 (L8) pups per mother during lactation to induce a differential consumption of maternal milk. After weaning all pups were fed with a diet high in saturated fat ?HF? (40% of energy from lipids) until adulthood. At 55 days of age, the animals were treated with a single dose of dimethylbenzanthracene to study tumor latency, incidence and progression. Histological and immunohistochemical studies were performed. We observed that animals that maintained high milk intake (L3) had lower mammary cancer incidence than animals that maintained lower milk consumption (L8; P