PLATELETS PROMOTE B. abortus MONOCYTE INVASION BY ESTABLISHING COMPLEXES WITH MONOCYTES

TROTTA, ALDANA; VELÁSQUEZ, LIS N.; M. AYELÉN MILILLO,; DELPINO, M. VICTORIA; RODRIGUEZ ANA; LANDONI, VERÓNICA; GIANBARTOLOMEI, GUILLERMO; POZNER R.G; PAULA BARRIONUEVO

Simposio; Simposio Frontiers in Bioscience; 2018

Brucellosis is an infectious disease elicited by bacteria of the genus Brucella. Platelets have been recently involved in the modulation of both innate and adaptive immune responses. Although many interactions have been described between B. abortus and monocytes/macrophages, the role of platelets during the infection remained unknown. Thus, the aim of this study was to investigate the role of platelets in the immune response against B. abortus. We first focused on the possible interactions between B. abortus and platelets. Our results showed that platelets were able to interact with bacteria in a dose-dependent fashion. Moreover, this interaction triggered platelet activation, measured as fibrinogen binding and P-selectin expression (p